egnite, Inc. Unveils Research on Mitral Regurgitation at Transcatheter Cardiovascular Therapeutics Conference 2023

egnite, Inc. Unveils Research on Mitral Regurgitation at Transcatheter Cardiovascular Therapeutics Conference 2023

Led by Rahul Sharma MBBS, FRACP, and Colleagues, Findings Presented Today at the TCT Conference 

Key Findings Demonstrate Patients with Moderate-to-Severe Mitral Regurgitation are 3 Times Less Likely to be Treated Than Patients with Severe Mitral Regurgitation Despite Similar Untreated Mortality. 

ALISO VIEJO, Calif. – October 25, 2023 egnite, Inc., a leading cardiovascular digital health company, announced today that novel research on mitral regurgitation (MR) was presented by cardiologist Rahul Sharma, MBBS, FRACP, at the Transcatheter Cardiovascular Therapeutics (TCT) conference.

The study, the second presentation of egnite’s data at TCT, leveraged egnite’s de-identified real-world database of over one million patients across 25 teaching and non-teaching US health systems. These findings unveiled critical insights into treatment patterns and associated outcomes in patients with MR.

Key findings demonstrated:

  • Patients with moderate-to-severe MR and severe MR exhibit similar untreated mortality, with untreated 2-year mortality rates at 30.2% and 31.8%, respectively
  • Moderate-to-severe MR is 3 times less likely to be treated than severe MR, indicated by 2-year interventional treatment rates at 13.5% and 46.4%, respectively

 

Sharma, Director of Structural Interventions, Associate Director of the Cardiac Catheterization Laboratory, and Associate Professor of Medicine, emphasized, “These findings underscore the urgency of early intervention for patients with MR. The implications of delayed treatment, particularly in moderate-to-severe MR, cannot be overstated, as it may lead to poor patient outcomes.”

Further analyses by type of severe MR (primary, secondary, and mixed MR) reveal varying intervention and mortality rates, underscoring the importance of individualized treatment approaches.

This research represents one of the largest real-world analyses of treatment patterns and associated outcomes for patients with MR and highlights the importance of timely intervention. egnite continues to be at the forefront of real-world insights in cardiovascular care.

 

About egnite, Inc.

egnite is a visionary digital health company committed to advancing the health of our society through innovative cardiovascular solutions. egnite uses AI-driven algorithms and big data to produce business intelligence for healthcare, elevating the role of data in critical decisions. The company, based in Aliso Viejo, California, partners with leading hospitals and life sciences organizations to transform care delivery for cardiovascular patients. For more information, visit www.egnitehealth.com.

Related Articles

egnite Research

SGLT2i + GLP-1 RA: A Dynamic Duo in HFpEF?

Heart failure with a preserved ejection fraction (HFpEF) accounts for more than half of all heart failure cases and carries significant morbidity and mortality risk, especially after hospitalization1. Historically, management of the disease is largely focused on comorbidity management and lifestyle modifications, given that available therapies had not demonstrated sufficient impact on hospitalization burden or mortality. In recent years, however, the treatment paradigm for HFpEF has shifted, with a growing emphasis on SGLT2 inhibitors (SGLT2i). Originally developed to lower blood glucose levels in diabetic patients, several clinical trials have firmly established that SGLT2i is also beneficial for patients living with HFpEF2.

Figure 1: Observed Mortality Stratified by GLP-1 RA and/or SGLT2i Prescription
egnite Research

Two-Year Mortality Following Heart Failure Hospitalization in Patients with HFpEF Stratified by SGLT2i and GLP-1 RA Therapy: A Real-World Analysis

BACKGROUND Heart failure with a preserved ejection fraction (HFpEF) is characterized by frequent hospitalizations, and substantial mortality. While historically lacking effective therapies, newer treatments, including SGLT2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP-1 RA), have shown potential benefits. However, the clinical course of HFpEF under these therapies remains incompletely characterized,

egnite Research

What the EARLY TAVR Trial Data Could Mean for Already Busy Heart Teams 

On the heels of the exciting EARLY TAVR data and egnite’s Acute Valve Syndrome in Aortic Stenosis study, both led by Dr. Philippe Genereux, we’ve been asked by several cardiovascular (CV) administrators what a potential change in the management of asymptomatic severe aortic stenosis (SAS) patients could mean for their already busy heart teams.